Evidence-based medicine in the treatment of non-small-cell lung cancer

Clin Chest Med. 2000 Mar;21(1):107-20, ix. doi: 10.1016/s0272-5231(05)70011-3.


Treatment decisions for non-small-cell lung cancer require accurate initial staging of patients. Typically surgical resection is recommended for early stage disease, while chemotherapy in conjunction with radiotherapy and possibly surgical resection is recommended for selected patients with locally advanced disease. Chemotherapy clearly has been demonstrated to improve survival and quality of life in metastatic disease. Surgical, chemotherapeutic, and radiotherapy treatment options as well as the role of multi-modality therapy will be discussed focusing on the evidence for various stages of non-small-cell lung cancer.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / surgery*
  • Chemotherapy, Adjuvant
  • Evidence-Based Medicine
  • Humans
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery*
  • Neoplasm Staging
  • Radiotherapy, Adjuvant
  • Randomized Controlled Trials as Topic
  • Survival Rate


  • Antineoplastic Agents