The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment

Laryngoscope. 2000 Apr;110(4):635-40. doi: 10.1097/00005537-200004000-00018.


Objectives: To describe a new treatment modality of olfactory neuroblastoma consisting of endoscopic nasal and paranasal sinus surgery and stereotactic radiosurgery.

Study design: Retrospective review of three patients suffering from olfactory neuroblastoma.

Methods: Review of the charts, the computed tomography, and magnetic resonance imaging scans, the operation reports, radiosurgical data, and follow-up.

Results: All three patients remained free of disease with excellent quality of life in respective follow-up periods of 71, 50, and 39 months.

Conclusion: The combination of two minimally invasive therapies, endoscopic sinus surgery and stereotactic radiosurgery, provide a reliable new approach to the treatment of a series of olfactory neuroblastomas that offers excellent quality of life, less injury to the patient, fewer side-effects, and fewer long-term effects than other treatment strategies.

MeSH terms

  • Adult
  • Aged
  • Combined Modality Therapy
  • Endoscopy*
  • Esthesioneuroblastoma, Olfactory / pathology
  • Esthesioneuroblastoma, Olfactory / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nasal Cavity / pathology
  • Nasal Cavity / surgery*
  • Neoplasm Staging
  • Nose Neoplasms / pathology
  • Nose Neoplasms / surgery*
  • Radiosurgery*
  • Reoperation
  • Retrospective Studies