Autoreactivity against matrilin-1 in a patient with relapsing polychondritis

Arthritis Rheum. 2000 Apr;43(4):939-43. doi: 10.1002/1529-0131(200004)43:4<939::AID-ANR28>3.0.CO;2-Z.


Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibody Formation
  • Autoantibodies / immunology
  • Blotting, Western
  • Cartilage
  • Cartilage Oligomeric Matrix Protein
  • DNA / isolation & purification
  • Extracellular Matrix Proteins / immunology*
  • Glycoproteins / immunology*
  • Granulocytes / chemistry
  • Histocompatibility Testing
  • Humans
  • Immunity, Cellular
  • Matrilin Proteins
  • Polychondritis, Relapsing / immunology*


  • Autoantibodies
  • Cartilage Oligomeric Matrix Protein
  • Extracellular Matrix Proteins
  • Glycoproteins
  • MATN1 protein, human
  • Matrilin Proteins
  • TSP5 protein, human
  • DNA