Salubrious effect of vitamin C and vitamin E on tamoxifen-treated women in breast cancer with reference to plasma lipid and lipoprotein levels

Cancer Lett. 2000 Apr 3;151(1):1-5. doi: 10.1016/s0304-3835(99)00340-7.


Tamoxifen, a non-steroidal antiestrogen, has been used in the hormonal treatment for breast cancer. The hepatic estrogenic effect of tamoxifen causes severe triglyceridemia. The combined effect of tamoxifen, vitamin C and vitamin E on plasma lipid and lipoprotein is important, since, vitamin C and vitamin E encumbered the lipid abnormalities instigated by tamoxifen. Therefore supplementation of vitamin C (Celin 500 mg) and vitamin E (Evion 400 mg) for 90 days along with tamoxifen (10 mg twice a day) to postmenopausal breast cancer patients was ventured. In tamoxifen-treated patients, total cholesterol (TC), free cholesterol (FC), phospholipids (PL), free fatty acids (FFA), low density lipoprotein cholesterol (LDL) levels were decreased and the triglycerides (TG), ester cholesterol (EC), high density lipoprotein cholesterol (HDL) and very low density lipoprotein cholesterol (VLDL) levels were increased. Combination therapy reduce all the cholesterol level and VLDL, LDL. TG levels were significantly decreased and HDL, EC levels were significantly increased. These results suggested that tamoxifen treatment is the most effective during co-administration of vitamin C and vitamin E in that they reduce the tamoxifen-induced hypertriglyceridemia.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Hormonal / adverse effects
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Ascorbic Acid / therapeutic use*
  • Breast Neoplasms / blood*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / surgery
  • Cholesterol / blood
  • Cholesterol Esters / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cholesterol, VLDL / blood
  • Fatty Acids, Nonesterified / blood
  • Female
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood*
  • Middle Aged
  • Phospholipids / blood
  • Tamoxifen / adverse effects
  • Tamoxifen / therapeutic use*
  • Triglycerides / blood
  • Vitamin E / therapeutic use*


  • Antineoplastic Agents, Hormonal
  • Cholesterol Esters
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Fatty Acids, Nonesterified
  • Lipids
  • Lipoproteins
  • Phospholipids
  • Triglycerides
  • Tamoxifen
  • Vitamin E
  • Cholesterol
  • Ascorbic Acid