Iron-sulfur proteins: ancient structures, still full of surprises

J Biol Inorg Chem. 2000 Feb;5(1):2-15. doi: 10.1007/s007750050002.


This article is a survey of the properties and functions of Fe-S proteins under the following headings: sulfur and iron; iron-sulfur clusters; evolution of cofactor use; early observations; complex and extended clusters; sulfur exchange and core interconversions; synthesis and biosynthesis of Fe-S clusters; functions of Fe-S clusters: electron transfer, electron delocalization, spin states and magnetism, covalency of sulfur bonds; non-electron transfer functions of Fe-S clusters: substrate binding and catalysis, regulatory and sensing functions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Evolution, Molecular
  • Iron-Sulfur Proteins / biosynthesis
  • Iron-Sulfur Proteins / chemistry*
  • Iron-Sulfur Proteins / genetics
  • Models, Molecular


  • Iron-Sulfur Proteins