Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom

FEBS Lett. 2000 Apr 14;471(2-3):165-8. doi: 10.1016/s0014-5793(00)01384-3.

Abstract

A novel peptide, scorpine, was isolated from the venom of the scorpion Pandinus imperator, with anti-bacterial activity and a potent inhibitory effect on the ookinete (ED(50) 0.7 microM) and gamete (ED(50) 10 microM) stages of Plasmodium berghei development. It has 75 amino acids, three disulfide bridges with a molecular mass of 8350 Da. Scorpine has a unique amino acid sequence, similar only to some cecropins in its N-terminal segment and to some defensins in its C-terminal region. Its gene was cloned from a cDNA library.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Antimicrobial Cationic Peptides*
  • Bacillus subtilis / drug effects
  • Bacillus subtilis / growth & development
  • Base Sequence
  • Cloning, Molecular
  • Defensins
  • Disulfides / metabolism
  • Dose-Response Relationship, Drug
  • Gametogenesis / drug effects
  • Germ Cells / drug effects
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / growth & development
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Molecular Weight
  • Peptides / chemistry
  • Peptides / pharmacology
  • Plasmodium berghei / drug effects
  • Plasmodium berghei / growth & development
  • Plasmodium berghei / physiology
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / isolation & purification*
  • Proteins / pharmacology*
  • Scorpion Venoms / chemistry*
  • Scorpion Venoms / genetics
  • Scorpion Venoms / pharmacology
  • Scorpions / chemistry
  • Scorpions / genetics
  • Sequence Homology, Amino Acid

Substances

  • Anti-Bacterial Agents
  • Antimalarials
  • Antimicrobial Cationic Peptides
  • Defensins
  • Disulfides
  • Peptides
  • Proteins
  • Scorpion Venoms
  • Shiva 3
  • scorpine