Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock

Crit Care Clin. 2000 Apr;16(2):289-317. doi: 10.1016/s0749-0704(05)70111-1.


Sepsis remains the leading cause of ARDS, and ARDS is still an often fatal condition. With our expanding knowledge of the pathobiologic mechanisms and the relationship between these two entities, early recognition, treatment, and prevention of sepsis may prevent or hasten recovery from ARDS. Understanding the biologic markers involved in the complex inflammatory response of sepsis and acute lung injury offers the possibility of future investigations to target treatment based on these mediators.

Publication types

  • Review

MeSH terms

  • Cell Adhesion Molecules / physiology
  • Cytokines / physiology
  • Fibrosis
  • Humans
  • Lung / pathology
  • Neutrophils / physiology
  • Nitric Oxide / physiology
  • Positive-Pressure Respiration
  • Respiration, Artificial / adverse effects
  • Respiratory Distress Syndrome / etiology*
  • Respiratory Distress Syndrome / pathology
  • Respiratory Distress Syndrome / physiopathology
  • Risk Factors
  • Sepsis / complications*
  • Shock, Septic / complications*


  • Cell Adhesion Molecules
  • Cytokines
  • Nitric Oxide