Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins

Diabetologia. 2000 Mar;43(3):285-93. doi: 10.1007/s001250050046.


Aims/hypothesis: To estimate the heritability of insulin sensitivity and insulin secretion, both of which are considered to contribute to the development of Type II (non-insulin-dependent) diabetes mellitus.

Methods: Intraclass correlation coefficients and heritability estimates for insulin sensitivity (euglycaemic clamp) as well as first-phase and late-phase insulin secretion (intravenous glucose tolerance test) were calculated in 21 monozygotic and 20 dizygotic twin pairs of the same sex between 54 and 72 years of age.

Results: Intrapair correlations for all traits were consistently higher in monozygotic than in dizygotic pairs. Insulin secretion correlated significantly only between monozygotic (first-phase r = 0.55; p = 0.003 and late-phase r = 0.66; p < 0.001) twins giving heritability estimates of 0.55 and 0.58, respectively. Insulin-stimulated glucose uptake showed a more modest correlation between monozygotic twins (r = 0.46; p = 0.015). The heritability estimate was 0.37. The heritability estimate for waist-to-hip ratio was 0.76 in female and 0.70 in male twins.

Conclusion/interpretation: Genetic variability seems to contribute to the variance of insulin sensitivity as well as of insulin secretion. In the current study, genetic variance accounted almost 60% for the variance in glucose-stimulated insulin secretion and almost 40% for the variance in insulin-stimulated glucose uptake. Our data is also compatible with findings in monogenic forms of diabetes in which genetic defects in insulin secretion play a predominant part in the pathogenesis of hyperglycaemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anthropometry
  • Cohort Studies
  • Female
  • Genetic Variation
  • Glucose / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance / genetics*
  • Insulin Secretion
  • Male
  • Middle Aged
  • Twins, Dizygotic*
  • Twins, Monozygotic*


  • Insulin
  • Glucose