Effect of baclofen on gait in spastic MS patients

Acta Neurol Scand. 2000 Apr;101(4):244-8. doi: 10.1034/j.1600-0404.2000.101004244x./.


Objectives: To measure gait and postural stability by objective methods in spastic MS patients and to evaluate the effect of baclofen on gait and postural stability.

Patients and methods: Fourteen spastic MS patients were examined in a placebo controlled double-blind, cross-over trial of oral baclofen treatment. The gait was measured on a computerized treadmill and postural stability was measured on a computer assisted force-plate.

Results: Only insignificant improvements in the clinical measurements during baclofen treatment were found. At baseline gait was characterized by low speed, short steps and unsteadiness. Postural stability was severely impaired. During baclofen treatment only vertical unsteadiness of gait diminished significantly.

Discussion: We conclude that patients primarily with spasticity, concomitant with hampering or painful spasms and co-contractions should be offered treatment with baclofen. Only some will experience improvement of their gait disorders, when treated with baclofen.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Baclofen / administration & dosage
  • Baclofen / therapeutic use*
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Gait / drug effects*
  • Gait Disorders, Neurologic / drug therapy*
  • Gait Disorders, Neurologic / etiology
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / drug therapy*
  • Muscle Relaxants, Central / administration & dosage
  • Muscle Relaxants, Central / therapeutic use*
  • Muscle Spasticity / drug therapy*
  • Muscle Spasticity / etiology
  • Posture
  • Treatment Outcome


  • Muscle Relaxants, Central
  • Baclofen