Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA

M Galimand; G Gerbaud; P Courvalin

doi:10.1128/AAC.44.5.1365-1366.2000

Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA

Antimicrob Agents Chemother. 2000 May;44(5):1365-6. doi: 10.1128/AAC.44.5.1365-1366.2000.

Authors

M Galimand¹, G Gerbaud, P Courvalin

Affiliation

¹ Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France. galimand@pasteur.fr

Abstract

Spectinomycin resistance in clinical isolates of Neisseria meningitidis and Neisseria gonorrhoeae was found to be due to mutations G1064C and C1192U (Escherichia coli numbering) in 16S rRNA genes, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Drug Resistance, Microbial / genetics
Escherichia coli / genetics
Humans
Neisseria gonorrhoeae / drug effects
Neisseria gonorrhoeae / genetics*
Neisseria meningitidis / drug effects
Neisseria meningitidis / genetics*
Point Mutation
RNA, Bacterial / genetics
RNA, Ribosomal, 16S / genetics*
Spectinomycin / pharmacology*

Substances

Anti-Bacterial Agents
RNA, Bacterial
RNA, Ribosomal, 16S
Spectinomycin