Successful treatment of a patient with nephrotic syndrome associated with chronic lymphocytic leukemia

Intern Med. 2000 Mar;39(3):256-9. doi: 10.2169/internalmedicine.39.256.

Abstract

We report the case of a 62-year-old man with nephrotic syndrome associated with stage B chronic lymphocytic leukemia (CLL). Kappa Bence Jones proteinuria and the glomerular deposition of kappa-light chain were observed. Although treatment with cyclophosphamide and prednisolone tended to reduce the level of proteinuria, the administration of angiotensin-converting enzyme inhibitor, enalapril, resulted in complete remission of nephrotic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Biopsy
  • Cyclophosphamide / therapeutic use
  • Drug Therapy, Combination
  • Enalapril / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Male
  • Middle Aged
  • Nephrotic Syndrome / drug therapy*
  • Nephrotic Syndrome / etiology
  • Nephrotic Syndrome / pathology
  • Prednisolone / therapeutic use
  • Remission Induction

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Immunosuppressive Agents
  • Enalapril
  • Cyclophosphamide
  • Prednisolone