The in Vivo Sensitivity of Plasmodium Falciparum to Chloroquine in the Red River Basin, Yunnan, China

Southeast Asian J Trop Med Public Health. 1998 Dec;29(4):692-5.

Abstract

The sensitivity of Plasmodium falciparum to chloroquine in vivo was examined out in a small town in the Red River basin from 1995 to 1996. forty cases were recruited into the present study, 32 cases were completely followed-up. The results of the in vivo study revealed that only 3 (9%) cases were sensitive to chloroquine, 29 (90.6%) showed resistance to chloroquine, among whom 7 cases (22%) showed resistance at RI, 12 cases (38%) at RII, and 10 cases (31%) at RIII. It is suggested that P. falciparum endemic areas should stop using chloroquine and other 4-aminoquinolines in the Red River basin now. Qinhaosu and pyronaridine were recommended to use as the first line antimalarial drugs of P. falciparum infection in the basin.

MeSH terms

  • Adult
  • Animals
  • Antimalarials / pharmacology*
  • China / epidemiology
  • Chloroquine / pharmacology*
  • Drug Resistance*
  • Female
  • Humans
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / epidemiology
  • Malaria, Falciparum / parasitology
  • Male
  • Plasmodium falciparum / drug effects*
  • Treatment Outcome

Substances

  • Antimalarials
  • Chloroquine