Abstract
Mice were infected via the ear pinna using a recombinant strain of HSV-1 expressing the beta-gal gene under the LAT promoter. Mice were treated continuously with valaciclovir or famciclovir, from 1 day before or 1 day after virus inoculation for 10 days. Ipsilateral and contralateral trigeminal and cervical ganglia were later assessed by co-cultivation or for X-Gal-positive or LAT-positive neurons. Latency was markedly reduced by early therapy, however, a basal level of HSV-1-positive neurons was detected in all mice.
MeSH terms
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2-Aminopurine / analogs & derivatives*
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2-Aminopurine / therapeutic use
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Acyclovir / analogs & derivatives*
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Acyclovir / therapeutic use
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Animals
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Antiviral Agents / therapeutic use*
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Famciclovir
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Herpes Simplex / drug therapy*
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Herpes Simplex / virology
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Humans
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In Situ Hybridization
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Mice
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Mice, Inbred Strains
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Neurons / virology*
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Prodrugs / therapeutic use*
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Simplexvirus / drug effects*
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Simplexvirus / physiology
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Trigeminal Ganglion / virology
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Valacyclovir
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Valine / analogs & derivatives*
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Valine / therapeutic use
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Virus Latency / drug effects*
Substances
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Antiviral Agents
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Prodrugs
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2-Aminopurine
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Valine
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Valacyclovir
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Famciclovir
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Acyclovir