Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs

Nucleosides Nucleotides Nucleic Acids. Jan-Feb 2000;19(1-2):501-13. doi: 10.1080/15257770008033024.

Abstract

The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / analogs & derivatives*
  • Acyclovir / therapeutic use
  • Administration, Topical
  • Animals
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Female
  • Guinea Pigs
  • Herpes Genitalis / drug therapy*
  • Herpes Genitalis / pathology
  • Herpes Labialis / drug therapy*
  • Herpes Labialis / pathology
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 2, Human / drug effects*
  • Mice
  • Mice, Hairless

Substances

  • Antiviral Agents
  • penciclovir
  • acyclovir monophosphate
  • Acyclovir