High frequency of altered HLA class I phenotypes in laryngeal carcinomas

Hum Immunol. 2000 May;61(5):499-506. doi: 10.1016/s0198-8859(00)00097-5.

Abstract

The exact frequency of HLA class I losses in human tumors is unknown. We have previously shown that primary breast and colorectal carcinomas frequently lose HLA class I molecules (88% and 73%, respectively). Now we report that this phenomenon is also a frequent event in laryngeal carcinomas. Of a total of 76 laryngeal carcinomas analyzed, 66% of the tumors showed an alteration in HLA class I phenotype. These altered HLA phenotypes were classified as total HLA loss (10.52%) (phenotype I); HLA-A locus-specific loss (13.15%) (phenotype IIIa); HLA-B locus-specific loss (10.52%) (phenotype IIIb); HLA allelic loss (27.63%) (phenotype IV); and HLA-A and B locus loss (3.9%). Comparison of histopathological parameters with HLA expression showed that poorly differentiated tumors had the lowest levels of HLA class I expression (p < 0.05).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / isolation & purification*
  • Carcinoma / genetics
  • Carcinoma / immunology*
  • Carcinoma / pathology
  • HLA Antigens / genetics
  • HLA Antigens / isolation & purification*
  • HLA-A Antigens / genetics
  • HLA-A Antigens / isolation & purification
  • HLA-B Antigens / genetics
  • HLA-B Antigens / isolation & purification
  • HLA-C Antigens / genetics
  • HLA-C Antigens / isolation & purification
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / isolation & purification*
  • Histocompatibility Testing
  • Humans
  • Laryngeal Neoplasms / genetics
  • Laryngeal Neoplasms / immunology*
  • Laryngeal Neoplasms / pathology
  • Loss of Heterozygosity
  • Mucous Membrane / immunology
  • Phenotype

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class I