Abstract
A reliable radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) has been developed based on [(18)10 mCi (370 MBq) of radiochemically pure [(18)1 Ci/micromol (37 GBq/micromol) at EOS within 100 min and in 13% radiochemical yield (end of bombardment (EOB); 7% end of synthesis (EOS)). [(18)F]FLT has been designed as a new positron emission tomography imaging agent for visualizing cellular proliferation in vivo based on the metabolism of thymidine.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Division
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Dideoxynucleosides / chemical synthesis*
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Fluorine Radioisotopes
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Indicators and Reagents
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Isotope Labeling / methods
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Molecular Conformation
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Radiopharmaceuticals / chemical synthesis*
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Spectrophotometry, Ultraviolet
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Thymidine / metabolism
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X-Ray Diffraction
Substances
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Dideoxynucleosides
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Fluorine Radioisotopes
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Indicators and Reagents
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Radiopharmaceuticals
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alovudine
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Thymidine