99mTc-ENS ventilation scintigraphy: preliminary study in human volunteers

Nucl Med Biol. 2000 Feb;27(2):215-8. doi: 10.1016/s0969-8051(99)00102-x.


Exogenous natural surfactant (ENS) labeled with (99m)Tc ((99m)Tc-ENS, 900-1110 MBq), a new radiopharmaceutical for ventilation scintigraphy, was nebulized during 3 min to five volunteers. For comparative purposes, (99m)Tc-diethylenetriamine pentaacetic acid (DTPA) was studied in the same way. (99m)Tc-ENS images were of at least the same quality as (99m)Tc-DTPA images. However, in smoking volunteers, the (99m)Tc-DTPA images show some areas that seemed to be not well-ventilated, although these areas appeared well-ventilated when the study was performed with (99m)Tc-ENS. These results suggest that (99m)Tc-ENS can be used for ventilation scintigraphy to allow the observation of some areas that cannot been visualized using (99m)Tc-DTPA as ventilation agent.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Lung / diagnostic imaging*
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Pulmonary Surfactants*
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Smoking / metabolism
  • Technetium Tc 99m Pentetate


  • Organotechnetium Compounds
  • Pulmonary Surfactants
  • Radiopharmaceuticals
  • Technetium Tc 99m Pentetate