Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization

Cytogenet Cell Genet. 2000;88(1-2):38-40. doi: 10.1159/000015481.

Abstract

Previously, a rodent cDNA encoding the third member of the Akt/PKB family of serine/threonine kinases was cloned. We have now cloned the human homolog of this cDNA, and we have used this clone to map the AKT3 gene to human chromosome 1q44 by fluorescence in situ hybridization (FISH). We have also mapped the rodent homologs of AKT3 to rat chromosome 13q24-->q26 and mouse chromosome 1H4-6 by FISH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosomes, Human, Pair 1 / genetics*
  • Cloning, Molecular
  • Fibroblasts
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Lymphocytes
  • Mice
  • Multigene Family / genetics*
  • Oncogene Proteins / genetics*
  • Physical Chromosome Mapping*
  • Protein-Serine-Threonine Kinases / genetics*
  • Proto-Oncogene Proteins c-akt
  • Rats
  • Sequence Homology, Amino Acid

Substances

  • Oncogene Proteins
  • AKT3 protein, human
  • Akt3 protein, mouse
  • Akt3 protein, rat
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt