Urinary 1-hydroxypyrene as a biomarker of polycyclic aromatic hydrocarbons exposure of workers on a contaminated site: influence of exposure conditions

J Occup Environ Med. 2000 Apr;42(4):391-7. doi: 10.1097/00043764-200004000-00013.


The aim of the study was to determine the exposure levels of workers to polycyclic aromatic hydrocarbons on gasworks sites by the measurement of urinary 1-hydroxypyrene. Start-shift and end-shift urine samples were taken every day during an entire week (Monday to Friday), once in November and a second time in June. Four groups of workers were selected according to their activity. Increased exposure was only found among volunteers involved in the remediation of a site, 0.16 to 2.31 mumol/mol creatinine in non-smokers. The median of the non-smoker referent group was 0.02 mumol/mol creatinine (95% confidence interval, 0.01 to 0.04). Smokers had greater exposure levels than non-smokers in every group. Within and between variability was around 200%. Assessment of the exposure of persons on contaminated soil is possible, with the condition that the exposed subjects come in direct contact with the soil.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Biomarkers
  • Female
  • Humans
  • Male
  • Occupational Exposure / analysis*
  • Occupational Exposure / statistics & numerical data
  • Paris
  • Polycyclic Aromatic Hydrocarbons / urine*
  • Pyrenes / metabolism*
  • Smoking
  • Soil Pollutants / urine*


  • Biomarkers
  • Polycyclic Aromatic Hydrocarbons
  • Pyrenes
  • Soil Pollutants
  • 1-hydroxypyrene