[123I]FP-CIT binding in rat brain after acute and sub-chronic administration of dopaminergic medication

Eur J Nucl Med. 2000 Mar;27(3):346-9. doi: 10.1007/s002590050044.


The recently developed radioligand [123I]FP-CIT is suitable for clinical single-photon emission tomography (SPET) imaging of the dopamine (DA) transporter in vivo. To date it has remained unclear whether dopaminergic medication influences the striatal [123I]FP-CIT binding. The purpose of this study was to investigate the influence of this medication on [123I]FP-CIT binding in the brain. We used an animal model in which we administered dopaminomimetics, antipsychotics and an antidepressant. In vivo [123I]FP-CIT binding to the DA and serotonin transporters was evaluated after subchronic and acute administration of the drugs. The administered medication induced small changes in striatal [123I]FP-CIT binding which were not statistically significant. As expected, the DA reuptake blocker GBR 12,909 induced a significant decrease in [123I]FP-CIT binding. [123I]FP-CIT binding in the serotonin-rich hypothalamus was decreased only after acute administration of fluvoxamine. The results of this study suggest that dopaminergic medication will not affect the results of DA transporter SPET imaging with [123I]FP-CIT.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Cerebellum / metabolism
  • Corpus Striatum / metabolism
  • Dopamine Agonists / administration & dosage
  • Dopamine Agonists / pharmacology*
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / pharmacology*
  • Dopamine Uptake Inhibitors / pharmacology
  • Hypothalamus / metabolism
  • Iodine Radioisotopes / pharmacokinetics*
  • Male
  • Piperazines / pharmacology
  • Rats
  • Rats, Wistar
  • Tropanes / pharmacokinetics*


  • Dopamine Agonists
  • Dopamine Antagonists
  • Dopamine Uptake Inhibitors
  • Iodine Radioisotopes
  • Piperazines
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
  • vanoxerine