Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7

Genomics. 2000 Apr 1;65(1):81-3. doi: 10.1006/geno.2000.6130.

Abstract

The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1. This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY. We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amine Oxidase (Copper-Containing)*
  • Animals
  • Carrier Proteins / genetics
  • Cell Line
  • Chromosome Mapping
  • Chromosomes / genetics
  • Chromosomes, Human, Pair 7 / genetics*
  • DNA / chemistry
  • DNA / genetics
  • Diabetes Mellitus, Type 1 / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • Lymphopenia / genetics*
  • Molecular Sequence Data
  • Polymorphism, Single-Stranded Conformational
  • RNA, Small Cytoplasmic / genetics
  • Rats
  • Rats, Inbred BB
  • Rats, Inbred BN
  • Sequence Analysis, DNA

Substances

  • Carrier Proteins
  • RNA, Small Cytoplasmic
  • DNA
  • Amine Oxidase (Copper-Containing)
  • AOC1 protein, human

Associated data

  • GENBANK/AF188753