Promoter prediction on a genomic scale--the Adh experience

Genome Res. 2000 Apr;10(4):539-42. doi: 10.1101/gr.10.4.539.


We describe our statistical system for promoter recognition in genomic DNA with which we took part in the Genome Annotation Assessment Project (GASP1). We applied two versions of the system: the first uses a region-based approach toward transcription start site identification, namely, interpolated Markov chains; the second was a hybrid approach combining regions and signals within a stochastic segment model. We compare the results of both versions with each other and examine how well the application on a genomic scale compares with the results we previously obtained on smaller data sets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Animals
  • Databases, Factual*
  • Drosophila melanogaster / enzymology*
  • Drosophila melanogaster / genetics*
  • Genes, Insect / genetics
  • Probability
  • Promoter Regions, Genetic / genetics*
  • Sequence Analysis, DNA / statistics & numerical data
  • Software*


  • Alcohol Dehydrogenase