Tumor formation suppressed in gammadeltaT knock-out mice

Cancer Lett. 2000 May 29;153(1-2):63-6. doi: 10.1016/s0304-3835(00)00343-8.

Abstract

Tumor formation was examined in mice in which the beta-chain gene of alphabetaT was knocked out (alphabetaT-KO mice) or the delta-chain gene of gammadeltaT was knocked out (gammadeltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alphabetaT-KO mice, in four of six wild-type mice, and in only one of six gammadeltaT-KO mice. These results imply that gammadeltaT cells play a role in suppression of killer cell activity in tumor-bearing mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / immunology*
  • Cell Transformation, Neoplastic / genetics
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neoplasm Transplantation
  • Receptors, Antigen, T-Cell, gamma-delta / genetics
  • Receptors, Antigen, T-Cell, gamma-delta / physiology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology*
  • Tumor Cells, Cultured

Substances

  • Receptors, Antigen, T-Cell, gamma-delta