Comparison of thermodynamic stabilities between PNA (peptide nucleic acid)/DNA hybrid duplexes and DNA/DNA duplexes

Nucleic Acids Symp Ser. 1999:(42):93-4. doi: 10.1093/nass/42.1.93.

Abstract

We have examined quantitatively stabilities of PNA/DNA hybrid duplexes with identical nearest-neighbor base pairs and compared stabilities between PNA/DNA and DNA/DNA. The average difference of stabilization energy of the short PNA/DNA was 0.9 kcal mol(-1), which suggests that the stability of the hybrids with identical nearest-neighbor base pairs can be predicted with the nearest-neighbor model as well as those of nucleic acid duplexes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • Base Sequence
  • Calorimetry
  • DNA / chemistry*
  • Drug Stability
  • Nucleic Acid Heteroduplexes / chemistry*
  • Oligodeoxyribonucleotides / chemistry*
  • Peptide Nucleic Acids / chemistry*
  • Thermodynamics

Substances

  • Nucleic Acid Heteroduplexes
  • Oligodeoxyribonucleotides
  • Peptide Nucleic Acids
  • DNA