Regulatory evolution and the origin of the bilaterians

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4430-3. doi: 10.1073/pnas.97.9.4430.

Abstract

The adult body plan of bilaterians is achieved by imposing regional specifications on pluripotential cells. The establishment of spatial domains is governed in part by regulating expression of transcription factors. The key to understanding bilaterian evolution is contingent on our understanding of how the regulation of these transcription factors influenced bilaterian stem-group evolution.

Publication types

  • Comment
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Body Patterning / genetics*
  • Embryo, Nonmammalian
  • Gene Expression Regulation
  • Genes, Homeobox
  • Invertebrates / classification*
  • Invertebrates / genetics*
  • Phylogeny
  • Transcription Factors / genetics

Substances

  • Transcription Factors