Tec family kinases in lymphocyte signaling and function

E M Schaeffer; P L Schwartzberg

doi:10.1016/s0952-7915(00)00088-1

Tec family kinases in lymphocyte signaling and function

Curr Opin Immunol. 2000 Jun;12(3):282-8. doi: 10.1016/s0952-7915(00)00088-1.

Authors

E M Schaeffer¹, P L Schwartzberg

Affiliation

¹ Department of Pathology, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. USA, USA. tschaeffer@uchichago.edu.

PMID: 10781397
DOI: 10.1016/s0952-7915(00)00088-1

Abstract

The Tec kinases are required for full Ca(2+) mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

B-Lymphocytes / immunology
Enzyme Activation
Lymphocytes / immunology*
Models, Immunological
Protein-Tyrosine Kinases / metabolism*
Receptors, Antigen / metabolism*
Receptors, Antigen, B-Cell / metabolism
Receptors, Antigen, T-Cell / metabolism*
Signal Transduction
T-Lymphocytes / immunology

Substances

Receptors, Antigen
Receptors, Antigen, B-Cell
Receptors, Antigen, T-Cell
Tec protein-tyrosine kinase
Protein-Tyrosine Kinases