Signal transduction by the TCR for antigen

Curr Opin Immunol. 2000 Jun;12(3):242-9. doi: 10.1016/s0952-7915(00)00083-2.


The past several years have seen the beginning of a shift in the way that TCR signal transduction is studied. Although many investigators continue to identify new molecules, particularly adaptor proteins, others have attempted to look at signaling events in a larger cellular context. Thus the identification of distinct formations of signaling molecules at junctions between T cells and antigen-presenting cells, the role of the cytoskeleton and the partitioning of molecules into specialized lipid subdomains have been the subjects of many publications. Such concepts are helping to assemble a blueprint of how the myriad adaptors and kinases fit together to effect T cell activation.

Publication types

  • Review

MeSH terms

  • Antigen Presentation*
  • Models, Immunological
  • Models, Structural
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • Transcription Factors / metabolism


  • Receptors, Antigen, T-Cell
  • Transcription Factors
  • Protein-Tyrosine Kinases