Chemokines in Tissue-Specific and Microenvironment-Specific Lymphocyte Homing

Curr Opin Immunol. 2000 Jun;12(3):336-41. doi: 10.1016/s0952-7915(00)00096-0.

Abstract

This review describes recent breakthroughs in our understanding of the roles played by chemokines in lymphocyte trafficking. These include the first demonstration that chemokines control lymphocyte/vascular recognition by shear-resistant rapid adhesion; the first example of specialized tissue-specific homing mediated by chemokines; and the implication that chemokines may control microenvironmental segregation within lymphoid organs.

Publication types

  • Review

MeSH terms

  • Cell Adhesion
  • Chemokine CCL21
  • Chemokines*
  • Chemokines, CC
  • Chemotaxis, Leukocyte / immunology*
  • Endothelium, Vascular / immunology
  • Immunologic Surveillance
  • Lymphocytes / immunology*
  • Models, Immunological
  • Receptors, CCR7
  • Receptors, Chemokine
  • Tissue Distribution

Substances

  • Chemokine CCL21
  • Chemokines
  • Chemokines, CC
  • Receptors, CCR7
  • Receptors, Chemokine