Ras regulation and function in lymphocytes

Curr Opin Immunol. 2000 Jun;12(3):289-94. doi: 10.1016/s0952-7915(00)00089-3.


The GTPase, Ras, is rapidly activated in antigen receptor stimulated T. cells, B cells and mast cells. Ras can bind to diverse effector molecules when activated and thereby switch on multiple downstream effector pathways. In lymphocytes Ras plays an important role in the signalling pathways that activate transcription factors involved in cytokine gene induction. Ras is also a key component of the complex regulatory networks that control T and B cell development.

Publication types

  • Review

MeSH terms

  • B-Lymphocytes / immunology*
  • GTP Phosphohydrolases / metabolism*
  • Gene Expression Regulation, Enzymologic
  • Guanine Nucleotide Exchange Factors
  • Models, Immunological
  • Signal Transduction
  • T-Lymphocytes / immunology*
  • Transcriptional Activation
  • ras Proteins / metabolism*


  • Guanine Nucleotide Exchange Factors
  • GTP Phosphohydrolases
  • ras Proteins