A central role for the endothelial NADPH oxidase in atherosclerosis

FEBS Lett. 2000 Apr 21;472(1):1-4. doi: 10.1016/s0014-5793(00)01397-1.


An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O2- to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O2-. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.

Publication types

  • Review

MeSH terms

  • Arteriosclerosis / enzymology*
  • Endothelium, Vascular / enzymology
  • Humans
  • Lipoproteins, LDL / metabolism
  • NADPH Oxidases / antagonists & inhibitors
  • NADPH Oxidases / metabolism*
  • Oxidation-Reduction
  • Superoxides / metabolism


  • Lipoproteins, LDL
  • Superoxides
  • NADPH Oxidases