Immunogenicity and reactogenicity of a group C meningococcal conjugate vaccine compared with a group A+C meningococcal polysaccharide vaccine in adolescents in a randomised observer-blind controlled trial

Vaccine. 2000 Jun 1;18(24):2686-92. doi: 10.1016/s0264-410x(00)00050-5.

Abstract

This study evaluated the immunogenicity and reactogenicity of a group C meningococcal conjugate vaccine (MenC) compared with a group A+C meningococcal polysaccharide vaccine (MenPS) in healthy adolescents. Subjects were randomised to receive one dose of either MenC (n=92) or MenPS (n=90). Group C meningococcal IgG antibody concentrations and bactericidal titres were higher in the MenC group than the MenPS group at 1 month (22.8 U/ml vs 4.0 U/ml, p<0.001, and 87 vs 20, p<0.001, respectively) and 12 months (6.1 U/ml vs 3.0 U/ml, p<0.001, and 81.3 vs 20.2, p<0.001, respectively). No differences in post immunisation reaction rates were noted between the two vaccinated groups. This study demonstrated the safety and enhanced immunogenicity of the candidate meningococcal conjugate vaccine as compared with the licensed polysaccharide vaccine in adolescents.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Antigens, Bacterial / immunology*
  • Bacterial Vaccines / immunology*
  • Child
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunization Schedule
  • Meningococcal Infections / prevention & control*
  • Neisseria meningitidis / immunology*
  • Polysaccharides, Bacterial / immunology*
  • Vaccines, Conjugate / immunology

Substances

  • Antigens, Bacterial
  • Bacterial Vaccines
  • Polysaccharides, Bacterial
  • Vaccines, Conjugate
  • meningococcal group A polysaccharide
  • meningococcal group C polysaccharide