Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

Toxicology. 2000 Apr 3;144(1-3):197-203. doi: 10.1016/s0300-483x(99)00207-3.


The factors with human P450 substrate selectivity are reviewed, together with extensive tabulation of quantitative relationships between structure and activity for many species of P450 substrates, inducers and inhibitors. In addition, the physicochemical characteristics (logP and pK(a) values) of heptic microsomal P450 substrates are collated, such that comparisons can be made on the grounds of compound lipophilicities.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemical Phenomena
  • Chemistry, Physical
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Lipids / chemistry*
  • Pharmaceutical Preparations / metabolism*
  • Structure-Activity Relationship


  • Isoenzymes
  • Lipids
  • Pharmaceutical Preparations
  • Cytochrome P-450 Enzyme System