CCL chemokines and asthma

Immunol Today. 2000 May;21(5):235-42. doi: 10.1016/s0167-5699(00)01634-0.

Abstract

Airway eosinophilia is a characteristic of bronchial asthma. Eosinophils are considered to cause tissue damage through the release of toxic proteases, lipid mediators, cytokines and oxygen free radicals. The discovery of chemokines and the demonstration that some members of this cytokine superfamily are implicated in the recruitment of eosinophils offers an opportunity for a novel therapeutic approach in asthma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Asthma / immunology*
  • Asthma / virology
  • Cell Movement / drug effects
  • Chemokine CCL11
  • Chemokine CCL5 / immunology*
  • Chemokine CCL5 / pharmacology
  • Chemokines, CC*
  • Chemotactic Factors, Eosinophil / immunology
  • Cytokines / chemistry
  • Cytokines / metabolism
  • Cytokines / pharmacology
  • Eosinophils / drug effects
  • Eosinophils / immunology
  • Epithelial Cells / metabolism
  • Humans
  • Ligands
  • Monocyte Chemoattractant Proteins / immunology
  • Monocyte Chemoattractant Proteins / pharmacology
  • Receptors, Chemokine / metabolism
  • Respiratory Mucosa / cytology
  • Respiratory Mucosa / immunology

Substances

  • CCL11 protein, human
  • Chemokine CCL11
  • Chemokine CCL5
  • Chemokines, CC
  • Chemotactic Factors, Eosinophil
  • Cytokines
  • Ligands
  • Monocyte Chemoattractant Proteins
  • Receptors, Chemokine