Phosphoinositide signaling and the regulation of membrane trafficking in yeast

Trends Biochem Sci. 2000 May;25(5):229-35. doi: 10.1016/s0968-0004(00)01543-7.


Phosphoinositides are key regulators of diverse cellular processes in eukaryotic cells. Genetic studies in yeast have advanced our understanding of how phosphoinositide-signaling pathways regulate membrane trafficking. Enzymes required for the synthesis (kinases) and turnover (phosphatases) of distinct phosphoinositides have been identified and several downstream effector molecules linked to phosphoinositide signaling have recently been characterized.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Biological Transport
  • Cell Membrane / metabolism
  • Humans
  • Molecular Sequence Data
  • Phosphatidylinositol 3-Kinases / chemistry
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphatidylinositols / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Sequence Homology, Amino Acid
  • Signal Transduction*


  • Phosphatidylinositols