AAA proteases: cellular machines for degrading membrane proteins

Trends Biochem Sci. 2000 May;25(5):247-51. doi: 10.1016/s0968-0004(99)01541-8.


AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts. They combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system. Inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans. Proteolysis by AAA proteases is modulated by another membrane-protein complex that is composed of prohibitins in eukaryotic cells and related proteins in bacteria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Hydrolysis
  • Membrane Proteins / metabolism*
  • Metalloendopeptidases / metabolism*


  • Membrane Proteins
  • Metalloendopeptidases
  • m-AAA proteases
  • Adenosine Triphosphatases