Abstract
Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents.
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Sulbactam / analogs & derivatives*
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Sulbactam / chemical synthesis
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Sulbactam / chemistry
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Sulbactam / pharmacology
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beta-Lactamase Inhibitors*
Substances
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Enzyme Inhibitors
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Prodrugs
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beta-Lactamase Inhibitors
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sulbactam pivoxyl
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Sulbactam