Seropositive rheumatoid arthritis with dermatomyositis sine myositis, angioimmunoblastic lymphadenopathy with dysproteinemia-type T cell lymphoma, and B cell lymphoma of the oropharynx

J Rheumatol. 2000 Apr;27(4):1087-90.

Abstract

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder that often progresses to high grade T cell lymphoma. We describe a 63-year-old woman with longstanding seropositive rheumatoid arthritis who developed fever, cutaneous findings of dermatomyositis, a diffuse pruritic maculopapular rash, enlarged lymph nodes, polyclonal elevated serum gammaglobulins, and an IgG lambda paraprotein. Lymph node biopsies yielded tissue with characteristic changes of AILD and T cell lymphoma. Interleukin 6 (IL-6) was present during the early, active phase of disease, and circulating IL-6 and IL-2 were detected one month before tumor recurrence. Two years after AILD and T cell lymphoma were diagnosed, she developed a B cell lymphoma that involved the oropharynx.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / pathology
  • Biomarkers
  • Biopsy
  • Blood Protein Disorders / complications*
  • Blood Protein Disorders / pathology
  • Dermatomyositis / complications*
  • Dermatomyositis / pathology
  • Fatal Outcome
  • Female
  • Humans
  • Immunoblastic Lymphadenopathy / complications*
  • Immunoblastic Lymphadenopathy / pathology
  • Lymph Nodes
  • Lymphoma, B-Cell / complications*
  • Lymphoma, B-Cell / pathology
  • Lymphoma, T-Cell / complications*
  • Lymphoma, T-Cell / pathology
  • Middle Aged
  • Oropharynx / pathology

Substances

  • Biomarkers