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, 48 (4), 505-8

Structures of 4-aryl-coumarin (Neoflavone) Dimers Isolated From Pistacia Chinensis BUNGE and Their Estrogen-Like Activity

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Structures of 4-aryl-coumarin (Neoflavone) Dimers Isolated From Pistacia Chinensis BUNGE and Their Estrogen-Like Activity

S Nishimura et al. Chem Pharm Bull (Tokyo).

Abstract

Activity-guided fractionation of twigs of Pistacia chinensis resulted in the isolation and characterization of two novel ingredients as potent estrogen agonists. On the basis of spectral analysis and comparison with a related compound their structures were elucidated as 3,3''-dimers of 4-aryldihydrocoumarins (3,4-dihydro-4-(4'-hydroxyphenyl)-7-hydroxycoumarin) differing only in the stereochemical disposition of the linkage between the two 4-arylcoumarin moieties. These compounds are the first examples of bis-flavonoids which have been proven to possess estrogen-like activity.

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