The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

Trends Microbiol. 2000 May;8(5):231-7. doi: 10.1016/s0966-842x(00)01728-5.


To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein. The staphylococcal transferrin receptor has been identified as a member of a newly emerging family of multifunctional, cell-surface-associated glyceraldehyde-3-phosphate dehydrogenases, which not only retain their glycolytic enzyme activities but also bind diverse human serum proteins and possess NAD-ribosylating activity. These multiple functions suggest a potential contribution to virulence far beyond iron acquisition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Wall / enzymology
  • Gene Expression Regulation, Bacterial
  • Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism*
  • Glycolysis
  • Humans
  • Iron / metabolism
  • Receptors, Transferrin / metabolism*
  • Staphylococcal Infections / microbiology
  • Staphylococcus / enzymology*
  • Staphylococcus / genetics
  • Staphylococcus / pathogenicity
  • Virulence


  • Receptors, Transferrin
  • Iron
  • Glyceraldehyde-3-Phosphate Dehydrogenases