Inflammation-coagulation network: are serine protease receptors the knot?

Trends Pharmacol Sci. 2000 May;21(5):170-2. doi: 10.1016/s0165-6147(00)01469-3.


Following an injury, the body recruits a mechanism to delimit and repair tissue damage; this phenomenon is known as inflammation. Among the several different pathways that are activated during this process, which is necessary for survival, activation of the coagulation pathway is a key feature. In fact, clinical changes in blood fluidity have been closely related to ongoing inflammation. Recent evidence suggests that serine protease receptors might play a major role in the host defence mechanism at the interface between coagulation and inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Coagulation / physiology*
  • Humans
  • Inflammation / pathology*
  • Receptor, PAR-1
  • Receptor, PAR-2
  • Receptors, Thrombin / genetics
  • Receptors, Thrombin / metabolism*
  • Serine Endopeptidases / chemistry
  • Serine Endopeptidases / metabolism*


  • Receptor, PAR-1
  • Receptor, PAR-2
  • Receptors, Thrombin
  • Serine Endopeptidases