A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF

Biochim Biophys Acta. 2000 Jan 31;1490(1-2):170-4. doi: 10.1016/s0167-4781(99)00211-0.


We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetyltransferases / chemistry
  • Acetyltransferases / genetics*
  • Amino Acid Sequence
  • Dosage Compensation, Genetic
  • Drosophila Proteins*
  • Histone Acetyltransferases
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins*
  • Saccharomyces cerevisiae Proteins*
  • Transfection


  • Drosophila Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • KAT7 protein, human
  • KAT8 protein, human
  • mof protein, Drosophila

Associated data

  • GENBANK/AF100615
  • GENBANK/AF117065