Interleukin-15 and its impact on neutrophil function

Curr Opin Hematol. 2000 May;7(3):174-7. doi: 10.1097/00062752-200005000-00008.


Interleukin-15 is a recently discovered cytokine produced by several cell types (including fibroblasts, keratinocytes, endothelial cells, and macrophages) in response to endotoxin or microbial infection. In turn, interleukin-15 has been shown to act on various cells of the immune system, including T and B lymphocytes, natural killer cells, monocytes, eosinophils, and circulating neutrophils. In the latter instance, interleukin-15 was initially observed to induce cytoskeletal rearrangements, to enhance phagocytosis, to increase the synthesis of several cellular proteins, and to delay apoptosis. Recently, interleukin-15 has been found to elicit other functional responses in neutrophils, such as chemokine production. This review recapitulates advances made in the area of interleukin-15/neutrophil interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation
  • Interleukin-15 / blood
  • Interleukin-15 / pharmacology*
  • Interleukin-15 / physiology
  • Neutrophil Activation / drug effects
  • Neutrophil Activation / genetics
  • Neutrophils / cytology
  • Neutrophils / drug effects*
  • Neutrophils / physiology


  • Interleukin-15