Fetal rhabdomyomatous nephroblastoma: diagnosis by fine-needle aspiration cytology--a case report

Diagn Cytopathol. 2000 Apr;22(4):235-7. doi: 10.1002/(sici)1097-0339(200004)22:4<235::aid-dc7>3.0.co;2-y.


The present report describes the case of a 21-mo-old boy with a fetal rhabdomyomatous nephroblastoma (FRN) diagnosed by fine-needle aspiration cytology (FNAC). The smears contained numerous isolated or clustered, deeply eosinophilic, thin, elongated rhabdomyoblasts with oval nuclei. Some of these cells presented cross-striations. Peculiar clusters of small, deeply eosinophilic, round cells with and without rounded nuclei in a mosaic pattern were interpreted as representing transversally oriented rhabdomyoblasts. Fetal rhabdomyoblasts were by far the predominant type of cell. Histology of the surgical specimen proved 90% of the mass to be constituted of fetal rhadomyomatous tissue. Adequate recognition of FRN is useful for the planning of treatment.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Infant
  • Kidney Neoplasms / diagnostic imaging
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Male
  • Rhabdomyoma / diagnostic imaging
  • Rhabdomyoma / pathology*
  • Rhabdomyoma / surgery
  • Ultrasonography
  • Wilms Tumor / diagnostic imaging
  • Wilms Tumor / pathology*
  • Wilms Tumor / surgery