A case of extramedullary plasmacytoma arising from the nasal septum

J Laryngol Otol. 2000 Jan;114(1):53-5. doi: 10.1258/0022215001903672.


A rare case of extramedullary plasmacytoma arising from the nasal septum with localized amyloid deposition is reported. A 75-year-old woman presented with a history of post-nasal discharge and nasal obstruction for several months. Endonasal endoscopic observation revealed the presence of a mass arising from her nasal septum with an extension to the nasopharynx. No cervical lymph nodes were palpable. The biopsy specimen was diagnosed as a plasmacytoma (IgG, lambda-light chain type). Both serum myeloma-protein and urine Bence-Jones protein were negative. Bone marrow biopsy, a chest radiograph, total body skeletal survey and 67Ga- and 99mTc-scintigrams showed no other systemic lesions. These findings confirmed the diagnosis of extramedullary plasmacytoma in the nasal septum. The patient received irradiation of 40 Gy without clinically detectable reduction of tumour size. The patient eventually underwent complete resection of the tumour by KTP/532 laser under endonasal endoscopic control. Pathologically, the tumour mass was composed mainly of amyloid deposition with a marked reduction of tumour cells. This indicated the radiosensitiveness of tumour cells, which was clinically masked by the increased amyloid deposition. The clinical presentation, pathological features and surgical procedures are described with a review of the literature.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amyloidosis / pathology
  • Female
  • Humans
  • Nasal Septum / diagnostic imaging
  • Nasal Septum / pathology*
  • Nasal Septum / surgery
  • Nose Diseases / pathology
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / radiotherapy
  • Nose Neoplasms / surgery
  • Plasmacytoma / diagnostic imaging
  • Plasmacytoma / pathology*
  • Plasmacytoma / surgery
  • Radiography