An exfoliative toxin A-converting phage isolated from Staphylococcus aureus strain ZM

Microbiol Immunol. 2000;44(3):189-91. doi: 10.1111/j.1348-0421.2000.tb02481.x.


Exfoliative toxin A (ETA) causes staphylococcal scalded-skin syndrome in children. The gene for ETA was believed to be coded by the chromosomal DNA. We isolated temperate phages from an ETA-producing strain, ZM, using a restriction minus strain, 1039, as an indicator. One of the prophages, designated phi-ZM-1 mediated lysogenic conversion of ETA. The polymerase chain reaction assay of the eta gene revealed that phage phi-ZM-1 carries the structural gene for ETA.

MeSH terms

  • Exfoliatins / biosynthesis
  • Exfoliatins / genetics*
  • Humans
  • Lysogeny
  • Microscopy, Electron
  • Polymerase Chain Reaction / methods
  • Staphylococcal Scalded Skin Syndrome / microbiology*
  • Staphylococcus Phages / genetics*
  • Staphylococcus Phages / isolation & purification*
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / metabolism
  • Staphylococcus aureus / virology*


  • Exfoliatins