Are selective COX-2 inhibitors nephrotoxic?

Am J Kidney Dis. 2000 May;35(5):937-40. doi: 10.1016/s0272-6386(00)70266-6.

Abstract

Nonsteroidal anti-inflammatory drugs are well-known culprits in the development of acute renal insufficiency in high-risk patients. The recent release of the selective cyclooxygenase-2 enzyme inhibitors for the treatment of inflammatory diseases and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects. However, the nephrotoxic potential of these agents in patients with prostaglandin-dependent states and chronic renal impairment is unknown. Many clinicians commonly wonder if these agents can be safely prescribed to such high-risk patients. We present two cases of acute renal failure complicating the course of therapy with celecoxib in patients with chronic renal insufficiency.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Celecoxib
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors / adverse effects*
  • Female
  • Humans
  • Isoenzymes / pharmacology*
  • Male
  • Membrane Proteins
  • Middle Aged
  • Peroxidases / antagonists & inhibitors*
  • Prostaglandin-Endoperoxide Synthases / pharmacology*
  • Pyrazoles
  • Renal Insufficiency / chemically induced*
  • Sulfonamides / adverse effects*

Substances

  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Membrane Proteins
  • Pyrazoles
  • Sulfonamides
  • Peroxidases
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases
  • Celecoxib