No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Neurosci Lett. 2000 May 12;285(2):147-9. doi: 10.1016/s0304-3940(00)01057-0.


We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Genetic Predisposition to Disease*
  • Haplotypes / genetics*
  • Humans
  • Population Surveillance*
  • Supranuclear Palsy, Progressive / epidemiology
  • Supranuclear Palsy, Progressive / genetics
  • Supranuclear Palsy, Progressive / pathology
  • tau Proteins / genetics*


  • tau Proteins