Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 355 (1395), 357-60

Memory in the B-cell Compartment: Antibody Affinity Maturation


Memory in the B-cell Compartment: Antibody Affinity Maturation

M S Neuberger et al. Philos Trans R Soc Lond B Biol Sci.


In the humoral arm of the immune system, the memory response is not only more quickly elicited and of greater magnitude than the primary response, but it is also different in quality. In the recall response to antigen, the antibodies produced are of higher affinity and of different isotype (typically immunoglobulin G rather than immunoglobulin M). This maturation rests on the antigen dependence of B-cell maturation and is effected by programmed genetic modifications of the immunoglobulin gene loci. Here we consider how the B-cell response to antigen depends on the affinity of the antigen receptor interaction. We also compare and draw parallels between the two processes, which underpin the generation of secondary-response antibodies: V gene somatic hypermutation and immunoglobulin heavy-chain class switching.

Similar articles

See all similar articles

Cited by 11 PubMed Central articles

See all "Cited by" articles


    1. Semin Immunol. 1996 Jun;8(3):159-68 - PubMed
    1. Curr Opin Immunol. 1995 Apr;7(2):248-54 - PubMed
    1. Immunity. 1998 Jul;9(1):127-34 - PubMed
    1. Adv Immunol. 1966;5:1-28 - PubMed
    1. Biochemistry. 1964 Jul;3:996-1008 - PubMed

MeSH terms

LinkOut - more resources