T-cell memory: lessons from Epstein-Barr virus infection in man

Philos Trans R Soc Lond B Biol Sci. 2000 Mar 29;355(1395):391-400. doi: 10.1098/rstb.2000.0579.


Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Viral / immunology
  • Herpesviridae Infections / epidemiology
  • Herpesviridae Infections / genetics
  • Herpesviridae Infections / immunology*
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Immunologic Memory / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Tumor Virus Infections / epidemiology
  • Tumor Virus Infections / genetics
  • Tumor Virus Infections / immunology*
  • Virus Latency / immunology


  • Antigens, Viral