Receptors mediating adenovirus attachment and internalization

Biochem Pharmacol. 1999 May 1;57(9):975-9. doi: 10.1016/s0006-2952(98)00332-3.


Adenovirus infection requires that the virus attach to cells and be internalized. Interaction between the viral fiber protein and specific cell surface receptors, such as the 46-kDa coxsackievirus and adenovirus receptor (CAR), is responsible for attachment; a second interaction between the viral penton base and cell surface integrins facilitates virus internalization. Expression of receptors may determine whether tissues are susceptible to adenovirus infection and adenovirus-mediated gene delivery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / chemistry
  • Adenoviridae / genetics
  • Adenoviridae / physiology*
  • Capsid / physiology
  • Capsid Proteins*
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / therapy
  • Genetic Therapy
  • Histocompatibility Antigens Class I / physiology
  • Humans
  • Receptors, Cell Surface / physiology
  • Receptors, Virus / physiology*


  • Capsid Proteins
  • Histocompatibility Antigens Class I
  • Receptors, Cell Surface
  • Receptors, Virus
  • penton protein, adenovirus